PT589. Characteristics of Cognitive function by the type of Neurocognitive disorder and Cognitive factors affecting severity classification of Neurocognitive disorder

s | 17 that only the years of education(β = -.38, p = .02) was significant to predict CS difference(adjusted R2 = .12, F(1, 37) = 6.27, p = .02). In the gray matter thickness analysis, thinner precuneus, cuneus and posterior cingulate gyrus predicted memory improvement(CS difference (p <0.05 RFT corrected)).; beta =-.37, t =4.16, number of vertex =231, Peak MNI coordinate(x, y, z) =(4.90, -68.97, 29.38). In DTI analysis, FA and RD of splenium corpus callosum were significantly associated with CS difference after FWE correction (p < .005); r =.35, p =.03 for FA; r =-.35, p =.03 for RD. Initial neuropsychological traits and brain morphology could be a promising method to predict cognitive enhancement after training. Poor strategies in memory and higher integrity of hippocampal network may be closely associated with outcomes of multi-strategic training based on metamemory concept. PT589 Characteristics of Cognitive function by the type of Neurocognitive disorder and Cognitive factors affecting severity classification of Neurocognitive disorder W.S. Seo, B.H. Koo, E.J. Cheon, H.K. Kim, Y.J. Lee, S.W. Lee, S.H. Yun, J.H. Choi, K.W. Lee, W.S. Choi, M.S. Keum. Department of Psychiatry, Yeungman University College of Medicine, Daegu, Republic of Korea. Abstract Objectives: The purpose of this study was to assess differences in cognitive function of patients with neurocognitive disorder by subtypes and severity, and to investigate the cognitive tests affecting severity classification of neurocognitive disorder. Methods: We retrospectively examined 132 patients diagnosed with Neurocognitive disorder(NCD) due to Alzheimer’s disease(AD), vascular neurocognitive disorder(VD) and traumatic brain injury(TBI) according to the Diagnostic and Statistical Manual of Mental Disorders fifth edition. All patients were administrated the Seoul Neuropsychological Screening Battery 2nd Edition and were classified into Major NCD and Mild NCD by clinical dementia rating score. Results: Major VD group exhibited greater impairment on Korean-Boston Naming Test(p=0.037), Digit symbol coding test(p=0.002), Korean-trail making test-Elderly’s version part A(p=0.031) than Major AD group. Major TBI group exhibited greater impairment on immediate recall in Seoul Verbal Learning Test-Elderly’s version(SVLT-E, p=0.04), letter fluency test in Controlled oral word association test(p=0.036), color reading test in Korean-color word stroop test(p=0.01), Digit symbol coding test(p=0.002), Korean-trail making test-Elderly’s version part A than Major AD group(p=0.031). Logistic regression analyses showed that cognitive tests affecting severity classification of neurocognitive disorder were Korean-Boston Naming Test(p<0.01) and SVLT-E(p<0.05) Conclusion: Despite the limitations of our study, it was indicated that AD, VD, and TBI had some differences in the neurocognitive functional impairment. The data also suggested that Korean-Boston Naming Test and memory function test could be a useful tool in classifying severity of neurocognitive disorder.